HRT Therapy

Vertisis Offers a Unique Solution for Hormone Replacement

The need for hormone replacement can onset at any age, either as the result of an injury, disease, genetics or simple aging. People tend to be most familiar with male and female specific hormone replacement as a bulwark against the decline of advancing age, but Vertisis is here to provide for the needs of any kind of needed hormone replacement be it for hypothyroidism or underactive adrenals. When it comes to hormone replacement, Vertisis has an edge over other pharmacies. We offer bioidentical hormone replacement whose chemical structure is identical to the hormones naturally produced by the human body. Since naturally occurring compounds cannot be patented, pharmaceutical companies add side chains to existing hormones so that they can be patented, but these extra side chains result in unwanted side effects and can result in difficulty for the body to remove these synthetic hormones after they have had their effect. For example, is the difference between Estrone, a naturally occurring type of estrogen in human females and Equillin, derived from pregnant horses. The only difference between these two molecules is a single extra double bond inside one of the ring structures present in the molecule, and yet that difference changes the pharmacologic clock on these molecules from about 12 hours to over 47 hours to be fully metabolized by the body [17]. As a physician, you know the serious difference between a drug that has its effect and leaves the body quickly as opposed to one that lingers and has the potential to build up within the body, which is why Equilin was quickly disused after initial exploratory experiments. But the example stands, even tiny changes to the chemical structure of the hormone can have drastic alterations in its efficacy.

When is Hormone Replacement Appropriate?

Hormone replacement therapy is generally accepted to be appropriate whenever the patient's own hormonal equilibrium is out of balance for whatever reason, assuming the same patient is also eligible to receive appropriate medication. In addition to the millions of men and women who can benefit from either testosterone or estrogen replacement respectively, a prevalence of 4.6% of the population of the United States is affected by hypothyroidism [18]. And there are many more conditions that would warrant the need for hormone replacement. More often, the people who could stand to benefit from hormone replacement are not even aware that the symptoms they are enduring have a solution, or think to ask their physician.

Why bioidentical hormone replacement is important

It has already been mentioned that pharmaceutical companies cannot patent naturally occurring compounds such as testosterone or the different estrogens, so they artificially introduce side chains in order to make their synthetic hormones more profitable. Take for example the differences between progesterone and progestin, which unfortunately are words still used almost interchangeably in the general public despite the serious differences. Progestin is a synthetic variant of progesterone that is often offered in HRT. However, it has been shown that women taking progestin lose much of the cardiovascular benefits associated with taking estrogen, another common component in female HRT. Also, progestin is associated with androgenic side effects, such as acne and hirsutism. The list of side effects for synthetic hormones goes on and on. Why should a physician bow to the pharmaceutical companies to take hormones altered for the sole purpose of increasing profits when Vertisis, a 503A compounding pharmacy, is here to offer the real deal when it comes to natural, bioidentical hormones? Stick with what the body already knows and choose Vertisis!


  1. [17] Bhavnani, B. R. (1998). Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine, 217(1), 6–16.
  2. [18] Skugor, M., & Fleseriu, M. (2010, August). Hypothyroidism and Hyperthyroidism. Current Clinical Medicine, 416-420. doi:10.1016/b978-1-4160-6643-9.00062-x